TGex uses VarElect, the Next Generation Sequencing Phenotyper, to score and prioritize variant-genes based on disease/phenotype of interest.
VarElect's interpretation engine leverages the GeneCards Suite Knowledgebase's powerful free text search engine, allowing for any phenotype to be entered, and ranking variants according to their association to the desired phenotype. This association is also supplemented by providing evidence for each association, which can further be investigated through direct access to more details in GeneCards, the Human Gene Database, and MalaCards, the Human Disease Database.
VarElect's unique advantage stems from its ability to leverage the extensive data available in the knowledgebase to infer direct, as well as indirect links, between genes and diseases/phenotypes.
Comprehensive annotation is crucial for browsing, filtering and selecting candidate variants. However, handling dozens of attributes per variant can be laborious and inefficient.
TGex was designed to simplify and consolidate numerous annotation attributes into a single view, enabling clear and straightforward analysis, including:
TGex provides analysts with all the tools required for filtering and ranking variants, together with the ability to quickly assess evidence for the association between candidate genes and relevant phenotypes, all in one easy-to-use, consolidated view.
TGex eliminates the need for manual collection of evidence, and helps provide the information required the way you want it.
Candidate variants and supporting evidence are collected from the GeneCards Knowledgebase automatically into a streamlined report which can be presented to the researcher or clinician. Relevant publications are also integrated into the report using a sophisticated algorithm.
Reports are customizable to fit your target audience, from the included data, to the complete design of each report.
Our HIPAA-ready, flexible infrastructure allows you to use TGex on the cloud, in your private cloud, or installed within your secure internal network.
When installed on premises, TGex can also import data from internal and licensed databases and data sources into analyses and reports, allowing you to extend the platform as needed.
TGex also integrates easily with your LIMS system and with your existing primary analysis pipeline using our easy-to-use APIs.